Acetyl chloride → N-[6-Bromo-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-acetamide

HRID 1497784Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1497784
[Br:1][C:2]1[C:3]([CH3:22])=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[C:5]2[N:6]([N:8]=[C:9]([NH2:11])[N:10]=2)[CH:7]=1.[C:23](Cl)(=[O:25])[CH3:24].ClCC(NC1N=C2C(C3C=CC=C(C(F)(F)F)C=3)=C(C)C(C3N(C4C=CC(C#N)=CC=4)N=CC=3)=CN2N=1)=O>>[Br:1][C:2]1[C:3]([CH3:22])=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[C:5]2[N:6]([N:8]=[C:9]([NH:11][C:23](=[O:25])[CH3:24])[N:10]=2)[CH:7]=1

Komponenten

4

Edukt 3

HCID 6367Acetyl chlorideHCID 867080876-Bromo-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamineHCID 86708103HCID 86708103, Verbindung

Produkt 1

HCID 86708104N-[6-Bromo-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-acetamide

Versuchsvorschrift

The title compound was prepared from 6-bromo-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (Int. 2, 6.7 g, 18.06 mmol) and acetyl chloride (2.83 mL, 39.7 mmol) using a similar method to that employed for Intermediate 17 (5.65 g).

Quellen und Nachweise

ORD-Eintrag
ord-3661dca7ab5644eebbe9dbcfd64b7787
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09199984B2

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