3-Fluoro-4-hydrazinylbenzonitrile → N-[6-[2-(4-Cyano-2-fluoro-phenyl)-2H-pyrazol-3-yl]-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-acetamide
Reaktionsgleichung
CN(C)[CH:3]=[CH:4][C:5]([C:7]1[C:8]([CH3:30])=[C:9]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=2)[C:10]2[N:11]([N:13]=[C:14]([NH:16][C:17](=[O:19])[CH3:18])[N:15]=2)[CH:12]=1)=O.[F:32][C:33]1[CH:34]=[C:35]([CH:38]=[CH:39][C:40]=1[NH:41][NH2:42])[C:36]#[N:37]>>[C:36]([C:35]1[CH:38]=[CH:39][C:40]([N:41]2[C:5]([C:7]3[C:8]([CH3:30])=[C:9]([C:20]4[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:28])([F:29])[F:27])[CH:21]=4)[C:10]4[N:11]([N:13]=[C:14]([NH:16][C:17](=[O:19])[CH3:18])[N:15]=4)[CH:12]=3)=[CH:4][CH:3]=[N:42]2)=[C:33]([F:32])[CH:34]=1)#[N:37]Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
The title compound was prepared from N-[6-(3-dimethylamino-acryloyl)-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-acetamide (Int. 25, 85 mg, 0.197 mmol) and 3-fluoro-4-hydrazino-benzonitrile (45 mg, 0.298 mmol) using similar methods to those employed in Example 40, Step 4 and Example 26, Step 1 (22 mg).