Hydrochloric Acid → (4-Fluorophenyl)(2-(piperazin-1-yl)pyrimidin-5-yl)methanone

HRID 1498844Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1498844
[F:1][C:2]1[CH:28]=[CH:27][C:5]([C:6]([C:8]2[CH:9]=[N:10][C:11]([N:14]3[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]3)=[N:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1.Cl>O1CCOCC1>[F:1][C:2]1[CH:28]=[CH:27][C:5]([C:6]([C:8]2[CH:9]=[N:10][C:11]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)=[N:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 118023371HCID 118023371, Verbindung

Produkt 1

HCID 118022709(4-Fluorophenyl)(2-(piperazin-1-yl)pyrimidin-5-yl)methanoneAusbeute 90,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a solution of tert-butyl 4-(5-(4-fluorobenzoyl)pyrimidin-2-yl)piperazine-1-carboxylate (8.2 g, 21.24 mmol) in dioxane (50 mL) was added HCl in dioxane (4 M, 20 mL). The reaction mixture was stirred at RT overnight. LCMS showed the reaction was completed. The mixture was concentrated to get the title compound as a light yellow solid (5.5 g, 90%). MS (ES+) C15H15FN4O requires: 286. found: 287 [M+H]+.

Aufarbeitung

  1. concentrationThe mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-b35c0e9897dc4767b5efa24714bbb4cb
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09200002B2

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