HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5-Methoxy[1,3]thiazolo[5,4-b]pyridin-2-amine → N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)-2-(10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-3-((R)-3-oxocyclopentyl)propionamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 5-Methoxy[1,3]thiazolo[5,4-b]pyridin-2-amine | HCID 2801557 | — |
| Edukt | methyl (1S)-3-oxocyclopentane-1-carboxylate | HCID 13827616 | — |
| Edukt | Ethyl (10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)acetate | HCID 59340971 | — |
| Edukt | (S)-7-iodomethyl-1,4-d ioxaspiro[4.4]nonane | HCID 67237087 | — |
| Produkt | N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)-2-(10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-3-((R)-3-oxocyclopentyl)propionamide | HCID 86637550 | — |
Reaktionsschritte
Analogously to Example 1 and Example 36, ethyl (10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)acetate, (S)-7-iodomethyl-1,4-d ioxaspiro[4.4]nonane (prepared analogously to Example 40 from commercially available methyl (S)-3-oxo-cyclopentanecarboxylate) and 5-methoxy-thiazolo[5,4-b]pyridin-2-ylamine give N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)-2-(10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-3-((R)-3-oxocyclopentyl)propionamide.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07732440B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-21acdf692c1a49009e3af8ed3e8a6972 |
| Quellennotiz | uspto-grants-2010_06 |