Iodide Ion → 3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)propionamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Iodide Ion	HCID 30165	—
Edukt	Ethyl-4,4-difluorocyclohexane carboxylate	HCID 2779138	—
Edukt	5-Methoxy[1,3]thiazolo[5,4-b]pyridin-2-amine	HCID 2801557	—
Edukt	tert-butyl 2-ethoxycarbonylmethyl-5,5-dioxo-5H-phenothiazine-10-carboxylate	HCID 59340981	—
Edukt	1,1-Difluoro-4-(iodomethyl)cyclohexane	HCID 67236985	—
Produkt	3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)propionamide	HCID 58024254	—

Reaktionsschritte

Analogously to Example 36 and Example 44, tert-butyl 2-ethoxycarbonylmethyl-5,5-dioxo-5H-phenothiazine-10-carboxylate, 1,1-difluoro-4-iodomethylcyclohexane (prepared from commercially available ethyl 4,4-difluorocyclohexanecarboxylate analogously to the synthesis of the iodide described in Example 40) and 5-methoxy-thiazolo[5,4-b]pyridin-2-ylamine give 3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)propionamide.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07732440B2
Quelldatensatz	uspto-grants-2010_06
ORD ID	ord-3958a078b667471db485796a4948a9a2
Quellennotiz	uspto-grants-2010_06