Hydrochloric Acid → 1-(1-Benzothiophen-4-yl)piperazine hydrochloride

HRID 1500551Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1500551
[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:8][CH:9]=[CH:10][C:3]1=2>CO>[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:8][CH:9]=[CH:10][C:3]1=2

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 210731871-(Benzo[b]thiophen-4-yl)piperazine

Produkt 1

HCID 574825411-(1-Benzothiophen-4-yl)piperazine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

3.7 ml of concentrated hydrochloric acid was added to a methanol solution of 9.5 g of 1-benzo[b]thiophen-4-yl-piperazine, and the solvent was evaporated under reduced pressure. Ethyl acetate was added to the residue and precipitated crystals were filtrated and recrystallized from methanol and 1-benzo[b]thiophen-4-yl-piperazine hydrochloride was obtained as colorless needle-like crystals.

Aufarbeitung

  1. customthe solvent was evaporated under reduced pressure
  2. additionEthyl acetate was added to the residue
  3. customprecipitated crystals
  4. filtrationwere filtrated
  5. customrecrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-e23b946abf22472783ad19580957631e
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09206167B2

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