Hydrochloric Acid → 2-Amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile

HRID 1501215Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1501215
[C:1](#[N:5])[CH2:2][C:3]#[N:4].[H-].[Na+].[CH2:8]=[C:9]1[O:13][C:11](=[O:12])[CH2:10]1.Cl>O1CCCC1>[NH2:4][C:3]1[O:13][C:9]([CH3:8])=[CH:10][C:11](=[O:12])[C:2]=1[C:1]#[N:5]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 8010MalononitrileHCID 12661DiketeneHCID 24758Sodium hydride

Produkt 1

HCID 114805352-Amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of malononitrile (3.3 g, 50 mmol) in 100 mL of anhydrous tetrahydrofuran was added sodium hydride (60%, 2.2 g, 55 mmol) at −10° C. The resulting reaction mixture was stirred for 2 hours. Then diketene (4.2 g, 50 mmol) was added dropwise to the solution. The reaction mixture was allowed to warmed to room temperature and continued to stir for 30 minutes. The mixture was neutralized with diluted hydrochloric acid, and then concentrated in vacuo to give crude 2-amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile as red solid, which was used in the next step without further purification.

Aufarbeitung

  1. customThe resulting reaction mixture
  2. stirringto stir for 30 minutes
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a2069df2caf245e5a399ef5c3c617da0
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09206128B2

Notizen zur Reaktion

Wird geladen…