Hydrochloric Acid → 2-Amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile

HRID 1501259Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1501259
[C:1](#[N:5])[CH2:2][C:3]#[N:4].[H-].[Na+].[CH2:8]=[C:9]1[O:13][C:11](=[O:12])[CH2:10]1.Cl>O1CCCC1>[NH2:4][C:3]1[O:13][C:9]([CH3:8])=[CH:10][C:11](=[O:12])[C:2]=1[C:1]#[N:5]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 8010MalononitrileHCID 12661DiketeneHCID 24758Sodium hydride

Produkt 1

HCID 114805352-Amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of malononitrile (3.3 g, 50 mmol) in anhydrous tetrahydrofuran (100 mL) was added sodium hydride (60%, 2.2 g, 55 mmol) at −10° C. The resulting reaction mixture was stirred for 2 hours. Then diketene (4.2 g, 50 mmol) was added dropwise to the solution. The reaction mixture was allowed to warmed to room temperature and continued to stir for 30 minutes. The mixture was neutralized with hydrochloric acid, and then concentrated in vacuo to give crude product as red solid, which was used in the next step without further purification.

Aufarbeitung

  1. customThe resulting reaction mixture
  2. stirringto stir for 30 minutes
  3. concentrationconcentrated in vacuo
  4. customto give crude product as red solid, which
  5. customwas used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-6375d35d2162482288e00c0bda8fb246
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09206128B2

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