Nitric Acid → 5-Chloro-2-methyl-3-nitrobenzoic acid

HRID 1501695

Reaktionsgleichung

Reaktionsgleichung von HRID 1501695
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[N+:12]([O-])([OH:14])=[O:13]>OS(O)(=O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

Komponenten

4

Edukt 2

HCID 944Nitric AcidHCID 820095-Chloro-2-methylbenzoic acid

Produkt 1

HCID 230097625-Chloro-2-methyl-3-nitrobenzoic acidAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel2×

Versuchsvorschrift

A stirred solution of 5-chloro-2-methylbenzoic acid (1 mmol) in conc. H2SO4 (2 mL) was cooled to −10° C. and nitrating mixture (0.4 mL of conc. H2SO4+0.1 mL of conc. HNO3) was added to it in dropwise manner. The reaction mixture was stirred at the same temperature for 20 min then warmed to room temperature. The solid precipitate was filtered and dried to obtain 5-chloro-2-methyl-3-nitrobenzoic acid which was used in next step without further purification (yield 60-70%).

Aufarbeitung

  1. filtrationThe solid precipitate was filtered
  2. customdried

Quellen und Nachweise

ORD-Eintrag
ord-bfab7be9238c446b8970d45b2006cf49
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09206157B2

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