Imidazole → 1-[3-Iodo-2,2-bis(octadecyloxymethyl)propoxy]octadecane

Temperatur

100 °C

2,2,2-Tris(octadecyloxymethyl)ethanol (500 mg, 560 μmol) was dissolved in toluene (10 ml), triphenylphosphine (294 mg, 1.12 mmol), imidazole (76.2 mg, 1.12 mmol) and iodine (284 mg, 1.12 mmol) were added, and the mixture was stirred at 100° C. overnight. The reaction mixture was cooled to room temperature, toluene (10 ml) was added, and the mixture was partitioned and washed three times with water (5 ml). The organic layer was evaporated under reduced pressure, and the residue was precipitated with acetonitrile (10 ml) to give 1-[3-iodo-2,2-bis(octadecyloxymethyl)propoxy]octadecane (555 mg, 553 μmol, yield 98%).

1. temperatureThe reaction mixture was cooled to room temperature
2. customthe mixture was partitioned
3. washwashed three times with water (5 ml)
4. customThe organic layer was evaporated under reduced pressure
5. customthe residue was precipitated with acetonitrile (10 ml)

ORD-Eintrag

ord-564e7d2faa0f48d9a365e10b029c419b

Quelldatensatz

uspto-grants-2015_12

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09206230B2