HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetone → Bazedoxifene
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetone | HCID 180 | — |
| Edukt | Azepane | HCID 8119 | — |
| Edukt | bazedoxifene 5-Benzyloxy-2(4-benzyloxyphenyl)-1-[4-(2-bromoethoxy)benzyl]-3-methyl-indole | HCID 131734316 | — |
| Lösungsmittel | Acetic Acid | HCID 176 | — |
| Produkt | Bazedoxifene | HCID 154257 | — |
Reaktionsschritte
European Patent Application No. 0802183 describes a synthesis of bazedoxifene 5-Benzyloxy-2(4-benzyloxyphenyl)-1-[4-(2-bromoethoxy)benzyl]-3-methyl-indole is reacted with azepan, under suitable reaction conditions, followed by deprotection to yield bazedoxifene, which on subsequent treatment with acetone and acetic acid gives bazedoxifene acetate.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09212172B2 |
| Quelldatensatz | uspto-grants-2015_12 |
| ORD ID | ord-30e213a5c70c49b3815a389b696eeaac |
| Quellennotiz | uspto-grants-2015_12 |