tert-Butyl methyl ether → Bazedoxifene Acetate

Beteiligte Stoffe

Reaktionsschritte

Bazedoxifene free base (400 mg) and methyl tert-butyl ether (30 mL) are mixed and stirred for about 10 minutes. Acetic acid (0.17 g) is added slowly through a dropper and the mixture is stirred overnight for solid formation. The solid is collected by filtration to afford 250 mg of crystalline bazedoxifene acetate Form D.

Herkunft & Nachweise