HCID 77058980, Verbindung → tert-Butyl 7-amino-6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

HRID 1503882Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1503882
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[N+:13]([O-])=O)[CH2:9][N:8]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:7][CH2:6]2>CO.[Ni]>[NH2:13][C:12]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N:8]([C:16]([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:17])[CH2:9]2)=[CH:4][C:3]=1[O:2][CH3:1]

Komponenten

4

Edukt 1

HCID 77058980HCID 77058980, Verbindung

Produkt 1

HCID 53439135tert-Butyl 7-amino-6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of the product of Example 53E (550 mg, 1.78 mmol) in methanol (10 mL) was added Raney Ni (55 mg) and the mixture was stirred at ambient temperature under hydrogen for 16 hours. The mixture was filtered, concentrated and dried under vacuum to give the crude title compound. MS: 279 (M+H+).

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated
  3. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-adf9e6a7e8214ed8bf0a4bb35ff173f7
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09212192B2

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