4-Nitrophenyl chloroformate → HCID 86730055, Verbindung

HRID 1504596Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1504596
[OH:1][CH:2]1[CH2:5][N:4]([C:6]2[CH:14]=[CH:13][C:9]([C:10]([NH2:12])=[O:11])=[CH:8][N:7]=2)[CH2:3]1.[C:15](Cl)(=[O:26])[O:16][C:17]1[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=1>C(Cl)Cl>[C:15](=[O:26])([O:16][C:17]1[CH:18]=[CH:19][C:20]([N+:23]([O-:25])=[O:24])=[CH:21][CH:22]=1)[O:1][CH:2]1[CH2:5][N:4]([C:6]2[CH:14]=[CH:13][C:9]([C:10](=[O:11])[NH2:12])=[CH:8][N:7]=2)[CH2:3]1

Komponenten

4

Edukt 2

HCID 821294-Nitrophenyl chloroformateHCID 78992995HCID 78992995, Verbindung

Produkt 1

HCID 86730055HCID 86730055, VerbindungAusbeute 10 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 6-(3-hydroxyazetidin-1-yl)nicotinamide (0.19 g, 1 mmol) in DCM (5 mL) under nitrogen was added 4-nitrophenyl carbonochloridate (0.20 g, 1 mmol). The resulting solution was stirred under N2 at room temperature for 24 h. The reaction mixture was then filtered and the filter cake was washed with DCM. The combined filtrates were concentrated to afford the title compound (36 mg, 10%) as a yellow liquid. [LCMS RtA=1.71 min, [M+H]+=359.0].

Aufarbeitung

  1. filtrationThe reaction mixture was then filtered
  2. washthe filter cake was washed with DCM
  3. concentrationThe combined filtrates were concentrated

Quellen und Nachweise

ORD-Eintrag
ord-df339d41ae98444dae31b6274123f3ed
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09216182B2

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