4-tert-Butylcyclohexanone → 1-[4-(Tert-butyl)-1-cyclohexen-1-YL]pyrrolidine

HRID 1504993

Reaktionsgleichung

Reaktionsgleichung von HRID 1504993
[C:1]([CH:5]1[CH2:10][CH2:9][C:8](=O)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[NH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1>C1(C)C=CC=CC=1>[C:1]([CH:5]1[CH2:10][CH2:9][C:8]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 73924-tert-ButylcyclohexanoneHCID 31268Pyrrolidine

Produkt 1

HCID 1072321-[4-(Tert-butyl)-1-cyclohexen-1-YL]pyrrolidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A 50 mL round-bottomed flask containing 4-tert-butylcyclohexanone (6.01 gm) in anhydrous toluene (20 mL) was fitted with a Dean-Stark trap containing 3A molecular sieves, reflux condenser and a heating mantle. Pyrrolidine (6.00 mL) was added, and the solution heated to reflux for 18 hr. The solvent was evaporated and the crude product was used directly for the next reaction.

Aufarbeitung

  1. customwas fitted with a Dean-Stark trap
  2. temperaturereflux condenser
  3. temperaturethe solution heated
  4. temperatureto reflux for 18 hr
  5. customThe solvent was evaporated
  6. customthe crude product was used directly for the next reaction

Quellen und Nachweise

ORD-Eintrag
ord-bcf3b8f806d74b62bb2d057e7b5ce976
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09216966B2

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