Trifluoroacetic acid → 2-(4-octylphenyl)ethyl Acetate

HRID 1505018Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1505018
[C:1]([O:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=O)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[CH:9][CH:8]=1)(=[O:3])[CH3:2].FC(F)(F)C(O)=O.C([SiH](CC)CC)C>>[C:1]([O:4][CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[CH:11][CH:12]=1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 217075284-Octanoylphenethyl acetate

Produkt 1

HCID 114827792-(4-octylphenyl)ethyl Acetate

Versuchsvorschrift

4-Octanoylphenethyl acetate (17.6 g) and trifluoroacetic acid (31 mL) are charged into a 250 mL single neck round bottom flask equipped with a guard tube and stirred for a few minutes. Triethylsilane (25.7 mL) is added and the mixture is stirred overnight at room temperature. The mixture is poured onto crushed ice and then extracted with ethyl acetate (3×100 mL). The organic layer is washed with sodium bicarbonate (200 mL), then with brine solution, dried with sodium sulphate, and concentrated under vacuum to give crude as brown color liquid. The crude is purified by silica gel column using hexane as the eluent to give the title compound. Yield 10 g

Aufarbeitung

  1. customequipped with a guard tube
  2. stirringthe mixture is stirred overnight at room temperature
  3. additionThe mixture is poured
  4. customonto crushed ice
  5. extractionextracted with ethyl acetate (3×100 mL)
  6. washThe organic layer is washed with sodium bicarbonate (200 mL)
  7. dry with materialwith brine solution, dried with sodium sulphate
  8. concentrationconcentrated under vacuum
  9. customto give crude as brown color liquid
  10. customThe crude is purified by silica gel column

Quellen und Nachweise

ORD-Eintrag
ord-6a75a9535c4f4ec3915597eeea04f14a
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09216943B2

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