Piperidine → 4-Piperidin-1-ylbenzonitrile

HRID 1505167Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1505167
Cl[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[NH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>>[N:10]1([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=2)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Komponenten

3

Edukt 2

HCID 8082PiperidineHCID 121634-Chlorobenzonitrile

Produkt 1

HCID 7667714-Piperidin-1-ylbenzonitrileAusbeute 89 %

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To commercially available 4-chlorobenzonitrile 17 (1 g, 7.26 mmol) 3 ml of piperidine were added and the reaction was heated at 100° C. for 72 hours in closed vessel. The reaction was evaporated and the residue was dissolved in AcOEt and washed with water and brine. The purification of the crude residue by chromatographic column using AcOEt 1/Petroleum ether 9 as eluant gave 1.2 g of a pale yellow oil. Yield=89% 1HNMR (DMSO, 200 MHz) δ 1.57 (6H, m), 3.34 (4H, m), 6.98 (2H, d, J=9 Hz), 7.53 (2H, d, J=9 Hz)

Aufarbeitung

  1. customThe reaction was evaporated
  2. dissolutionthe residue was dissolved in AcOEt
  3. washwashed with water and brine
  4. customThe purification of the crude residue by chromatographic column

Quellen und Nachweise

ORD-Eintrag
ord-1e0c9dab523544ef9e18f4b8b5dc5e5c
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09216975B2

Notizen zur Reaktion

Wird geladen…