Trifluoroacetic acid → HCID 67235885, Verbindung

HRID 1505341Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1505341
[CH3:1][C@@H:2]([NH:22]C(=O)OC(C)(C)C)[C:3]([NH:5][C:6]1[CH:7]=[N:8][C:9]([O:12][C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[C:15]([O:20][CH3:21])[CH:14]=2)=[CH:10][CH:11]=1)=[O:4].C(O)(C(F)(F)F)=O>ClCCl>[CH3:19][C:16]1[CH:17]=[CH:18][C:13]([O:12][C:9]2[N:8]=[CH:7][C:6]([NH:5][C:3](=[O:4])[C@@H:2]([CH3:1])[NH2:22])=[CH:11][CH:10]=2)=[CH:14][C:15]=1[O:20][CH3:21]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 710067841,1-dimethylethyl {(1R)-1-methyl-2-[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]-2-oxoethyl}carbamate2×

Produkt 1

HCID 67235885HCID 67235885, VerbindungAusbeute 98,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 1,1-dimethylethyl {(1R)-1-methyl-2-[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]-2-oxoethyl}carbamate (Intermediate 51, 350 mg) in dry dichloromethane (7.5 mL), TFA (2.5 mL, 32.4 mmol) was slowly added and the reaction mixture was stirred for 1.5 hours at room temperature. The solvent and the excess of TFA were evaporated and the residue was purified with an SCX cartridge (10 g) to afford the title compound as a colourless oil (258 mg).

Aufarbeitung

  1. customThe solvent and the excess of TFA were evaporated
  2. customthe residue was purified with an SCX cartridge (10 g)

Quellen und Nachweise

ORD-Eintrag
ord-20e3c46e54714a2eb530123888ffbbbd
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09216967B2

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