Trifluoroacetic acid → 4-[(E)-2-(4-hydroxyphenyl)vinyl]-1-{4-[2-(1-pyrrolidinyl)-ethoxy]phenyl}-1H-pyridin-2-one
Reaktionsgleichung
FC(F)(F)C(O)=O.CC([O:12][C:13]1[CH:18]=[CH:17][C:16](/[CH:19]=[CH:20]/[C:21]2[CH:26]=[CH:25][N:24]([C:27]3[CH:32]=[CH:31][C:30]([O:33][CH2:34][CH2:35][N:36]4[CH2:40][CH2:39][CH2:38][CH2:37]4)=[CH:29][CH:28]=3)[C:23](=[O:41])[CH:22]=2)=[CH:15][CH:14]=1)(C)C>>[OH:12][C:13]1[CH:18]=[CH:17][C:16](/[CH:19]=[CH:20]/[C:21]2[CH:26]=[CH:25][N:24]([C:27]3[CH:32]=[CH:31][C:30]([O:33][CH2:34][CH2:35][N:36]4[CH2:37][CH2:38][CH2:39][CH2:40]4)=[CH:29][CH:28]=3)[C:23](=[O:41])[CH:22]=2)=[CH:15][CH:14]=1Komponenten
3
Versuchsvorschrift
Trifluoroacetic acid (2 mL) was added to 4-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one (120 mg, 0.26 mmol) and stirred at room temperature for 30 minutes. After concentrating the reaction liquid under reduced pressure, chloroform was added to the reaction liquid which then was washed with aqueous sodium hydrogencarbonate solution and dried over anhydrous sodium sulfate. Concentrating the solvent under reduced pressure, the title compound (97 mg, 92%) was obtained as a white solid.
Aufarbeitung
- concentrationAfter concentrating
- customthe reaction liquid under reduced pressure, chloroform
- additionwas added to the reaction liquid which
- washthen was washed with aqueous sodium hydrogencarbonate solution
- dry with materialdried over anhydrous sodium sulfate
- concentrationConcentrating the solvent under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-241179f0589349129fa9c34052951db9
- Quelldatensatz
- uspto-grants-2010_06
- Patentnummer
- US07732456B2
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