Acetohydrazide → ethyl 5-methyl-4-(o-tolyl)-4H-1,2,4-triazole-3-carboxylate

HRID 1506629Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1506629
Cl[C:2](=[N:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH3:15])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[C:16]([NH:19][NH2:20])(=O)[CH3:17]>C(#N)C>[CH3:17][C:16]1[N:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:15])[C:2]([C:3]([O:5][CH2:6][CH3:7])=[O:4])=[N:20][N:19]=1

Komponenten

4

Edukt 2

HCID 14039AcetohydrazideHCID 90280270Ethyl 2-chloro-2-(o-tolylimino)acetate

Produkt 1

HCID 90281310ethyl 5-methyl-4-(o-tolyl)-4H-1,2,4-triazole-3-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

The suspension of 10B and acetohydrazide in acetonitrile was refluxed for 2 hours. The solvent was removed. The crude product was purified by flash column (Rf: 0.2, 50% EtOAc/Hexanes). MS (m/z) 246 [M+H]+.

Aufarbeitung

  1. temperaturewas refluxed for 2 hours
  2. customThe solvent was removed
  3. customThe crude product was purified by flash column (Rf: 0.2, 50% EtOAc/Hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-c87dde1f99f74e8ab8144f3ed86247ae
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09220710B2

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