Ammonia chloride → 1-(5-methyl-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)-2-phenylethanone

HRID 1506630Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1506630
[CH3:1][C:2]1[N:3]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])[C:4]([C:7]([O:9]CC)=O)=[N:5][N:6]=1.[CH2:19]([Mg]Cl)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[Cl-].N>C1(C)C=CC=CC=1>[CH3:1][C:2]1[N:3]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])[C:4]([C:7](=[O:9])[CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[N:5][N:6]=1

Komponenten

5

Edukt 3

HCID 20976574Ammonia chlorideHCID 90281310ethyl 5-methyl-4-(o-tolyl)-4H-1,2,4-triazole-3-carboxylateHCID 178418336HCID 178418336, Verbindung

Produkt 1

HCID 902812771-(5-methyl-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)-2-phenylethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a solution of 10C (1.0 g, 4.1 mmol) in toluene cooled by an ice bath, benzylmagnesium chloride (2M in THF) (3.0 mL, 6.0 mmol) was added dropwise. After one hour, ammonia chloride solution was added to the mixture and extracted with ethyl acetate (50 mL twice). The organic layer was dried with Na2SO4, filtered and concentrated and used without further purification. MS (m/z) 292 [M+H]+.

Aufarbeitung

  1. extractionextracted with ethyl acetate (50 mL twice)
  2. dry with materialThe organic layer was dried with Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customused without further purification

Quellen und Nachweise

ORD-Eintrag
ord-117dee3e4ab740fe9abba715ad453a5d
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09220710B2

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