Diethyl 2-(benzo[d]thiazol-2-yl)malonate → HCID 178451809, Verbindung

HRID 1507502

Reaktionsgleichung

[C:1]([CH:4]1[CH2:9][CH2:8][N:7]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6][CH2:5]1)(=[NH:3])[NH2:2].[S:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[C:18]1[CH:26]([C:32](OCC)=[O:33])[C:27](OCC)=[O:28]>C1(C)C=CC=CC=1>[S:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[C:18]1[C:26]1[C:32]([OH:33])=[N:3][C:1]([CH:4]2[CH2:9][CH2:8][N:7]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6][CH2:5]2)=[N:2][C:27]=1[OH:28]

Komponenten

Reaktionsbedingungen

Temperatur: 120 °C

Versuchsvorschrift

A mixture of tert-butyl 4-carbamimidoylpiperidine-1-carboxylate (35 g, 153.98 mmol, 1.00 equiv) and 1,3-diethyl 2-(1,3-benzothiazol-2-yl)propanedioate (49.7 g, 169.43 mmol, 1.10 equiv) in toluene (500 ml) was heated overnight at 120° C. in an oil bath under nitrogen. After cooled to room temperature, the solid was collected by filtration. 45 g of tert-butyl 4-[5-(1,3-benzothiazol-2-yl)-4,6-dihydroxypyrimidin-2-yl]piperidine-1-carboxylate was obtained as a light yellow solid. MS m/z [M+H]+ (ESI): 429.

Aufarbeitung

temperatureAfter cooled to room temperature
filtrationthe solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag: ord-a86ad43807cd4389ba07efb4203cdeb5
Quelldatensatz: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09221809B2

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