Hydrochloric Acid → HCID 178517540, Verbindung

HRID 1507504

Reaktionsgleichung

Reaktionsgleichung von HRID 1507504
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:11]([Cl:30])=[N:12][C:13]([CH:17]2[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)=[N:14][C:15]=1[OH:16].Cl>CO>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:15]([OH:16])=[N:14][C:13]([CH:17]2[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]2)=[N:12][C:11]=1[Cl:30]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 178451808HCID 178451808, Verbindung

Produkt 1

HCID 178517540HCID 178517540, VerbindungAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Into a solution of tert-butyl 4-[5-(1,3-benzothiazol-2-yl)-4-chloro-6-hydroxypyrimidin-2-yl]piperidine-1-carboxylate (44.7 g, 100.01 mmol, 1.00 equiv) in methanol (50 ml) was added concentrated hydrochloric acid (50 mL, 12 M). The resulting solution was stirred for 30 min at room temperature. Concentration under vacuum gave 34 g of 5-(1,3-benzothiazol-2-yl)-6-chloro-2-(piperidin-4-yl)pyrimidin-4-ol as a yellow solid, which was used directly for next step without further purification. MS m/z [M+H](ESI): 347.

Aufarbeitung

  1. concentrationConcentration under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-bd1135f847474bb9bc2305e9ca91e855
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09221809B2

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