Diethyl 2-(benzo[d]thiazol-2-yl)malonate → HCID 178517545, Verbindung

Beteiligte Stoffe

Reaktionsschritte

A solution of oxane-4-carboximidamide (160 mg, 1.25 mmol, 1.00 equiv), and 1,3-diethyl 2-(1,3-benzothiazol-2-yl)propanedioate (366 mg, 1.25 mmol, 1.00 equiv) in Toluene (3 mL) was heated for 3 h at 110° C. in an oil bath. After concentrated under reducing pressure, 460 mg (crude) of the title compound was obtained as a white solid, which was used directly for next step without further purification. MS m/z [M+H]+ (ESI): 330.

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