Cesium carbonate → 6-Bromo-1-(3-cyclopropoxypropyl)-3,3-dimethylindolin-2-one

To a suspension of 6-bromo-3,3-dimethylindolin-2-one (example 14a, 300 mg, 1.25 mmol) and Cs2CO3 (814 mg, 2.5 mmol) in DMF (2 ml) was added a solution of (3-bromopropoxy)cyclopropane (447 mg, 2.5 mmol) in DMF (0.5 ml). The reaction mixture was heated to 70° C. for 3 hours. The reaction mixture was filtered through sintered glass and concentrated. The crude material was purified by flash chromatography on silica gel using ethyl acetate as eluent. The title compound was obtained as orange viscous oil (360 mg).

1. filtrationThe reaction mixture was filtered through sintered glass
2. concentrationconcentrated
3. customThe crude material was purified by flash chromatography on silica gel

ORD-Eintrag

ord-eeb776ded8f2482daf1f5e5d5b8d17e0

Quelldatensatz

uspto-grants-2015_12

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09221816B2