Formamidine acetate → HCID 178522470, Verbindung

Reaktionsgleichung

C(O)(=O)C.[CH:5]([NH2:7])=[NH:6].[F:8][C:9]1[CH:26]=[CH:25][C:12]([C:13]([NH:15][CH:16]([C:21](OC)=[O:22])[C:17](OC)=[O:18])=[O:14])=[CH:11][CH:10]=1.[Na]>C(O)C>[OH:22][C:21]1[C:16]([NH:15][C:13](=[O:14])[C:12]2[CH:25]=[CH:26][C:9]([F:8])=[CH:10][CH:11]=2)=[C:17]([OH:18])[N:7]=[CH:5][N:6]=1

Komponenten

Versuchsvorschrift

Formamidine acetate (0.46 g, 4.46 mmol) and dimethyl 2-(4-fluorobenzamido)malonate (1.0 g, 3.71 mmol) were added to a solution of sodium (0.17 g, 7.43 mmol) in ethanol (37 ml). The reaction mixture was refluxed for 3 hours. After cooling down, the precipitate was filtered off and washed with ethanol. The product was dissolved in a minimal volume of water and acidified to pH 4-5 with 5M HCl. The precipitate was collected, washed with water and dried to yield the title compound as a white solid (0.60 g, 64%).