2-Pyridone → 4-[(5-Chloro-2-pyridinyl)methoxy]-1-(4-{[(2S)-1-ethyl-2-pyrrolidinyl]-methoxy}phenyl)-1H-pyridin-2-one
Reaktionsgleichung
N1C=CC=[CH:3][C:2]1=O.[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][O:16][C:17]2[CH:22]=[CH:21][N:20]([C:23]3[CH:28]=[CH:27][C:26]([O:29][CH2:30][C@@H:31]4[CH2:35][CH2:34][CH2:33][NH:32]4)=[CH:25][CH:24]=3)[C:19](=[O:36])[CH:18]=2)=[N:13][CH:14]=1>>[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][O:16][C:17]2[CH:22]=[CH:21][N:20]([C:23]3[CH:28]=[CH:27][C:26]([O:29][CH2:30][C@@H:31]4[CH2:35][CH2:34][CH2:33][N:32]4[CH2:2][CH3:3])=[CH:25][CH:24]=3)[C:19](=[O:36])[CH:18]=2)=[N:13][CH:14]=1Komponenten
3
Versuchsvorschrift
Example 123 was repeated except that 4-[(5-chloro-2-pyridinyl)methoxy]-1-4-{(3R)-3-pyrrolidinyl]oxy}phenyl)-2H-pyridin-2-one was replaced with 4-[(5-chloro-2-pyridinyl)methoxy]-1-(4-{[(2S)-2-pyrrolidinyl]methoxy}phenyl)-1H-pyridin-2-one, to provide the title compound.
Quellen und Nachweise
- ORD-Eintrag
- ord-649ebafba1b641aeb7be4a1cd45faf2a