Potassium Carbonate → HCID 66790112, Verbindung

HRID 1510159Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1510159
[CH:1]([CH:3]1[CH2:8][C:7](=[O:9])[CH2:6][CH2:5][NH:4]1)=[CH2:2].Cl[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH:19]([CH3:21])[CH3:20])[CH:13]=1.C([O-])([O-])=O.[K+].[K+]>C(#N)C>[CH:19]([O:18][C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=1)[CH2:11][N:4]1[CH2:5][CH2:6][C:7](=[O:9])[CH2:8][CH:3]1[CH:1]=[CH2:2])([CH3:21])[CH3:20]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 205693092-Ethenylpiperidin-4-oneHCID 295411551-(Chloromethyl)-3-isopropoxybenzene

Produkt 1

HCID 66790112HCID 66790112, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

2-vinylpiperidin-4-one (4.85 g, 38.7 mmol) in acetonitrile (40 ml) was added 1-(chloromethyl)-3-isopropoxybenzene (7.16 g, 38.7 mmol) and finely ground K2CO3 (16.1 g, 116 mmol). The mixture was stirred at 60° C. for 12 hrs. The solution was filtered, and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel Biotage 65i, eluting with 15% ethyl acetate/hexanes.

Aufarbeitung

  1. filtrationThe solution was filtered
  2. customthe solvent was evaporated under reduced pressure
  3. customThe residue was purified by column chromatography on silica gel Biotage 65i
  4. washeluting with 15% ethyl acetate/hexanes

Quellen und Nachweise

ORD-Eintrag
ord-9f5efcdc2e394b4b9bb9b8bb13a10979
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08211904B2

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