Hydrochloric Acid → HCID 59371243, Verbindung

HRID 1510282

Reaktionsgleichung

Reaktionsgleichung von HRID 1510282
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:19]=[CH:18][C:17]([NH:20][C:21]([C:23]3[N:24]=[C:25]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[O:26][C:27]=3[CH2:28][CH3:29])=[O:22])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>C(OCC)(=O)C>[NH:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:15]=[CH:16][C:17]([NH:20][C:21]([C:23]3[N:24]=[C:25]([C:30]4[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=4)[O:26][C:27]=3[CH2:28][CH3:29])=[O:22])=[CH:18][CH:19]=2)[CH2:10][CH2:9]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 674396964-{4-[(2-Phenyl-5-ethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 59371243HCID 59371243, VerbindungAusbeute 59,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To 4-{4-[(2-phenyl-5-ethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-1-carboxylic acid tert-butyl ester (330 mg, 0.694 mmol) was added 2N HCl in ethyl acetate (80 mL). The solution was stirred at room temperature for 1 hr. Solvents were evaporated and the residue was diluted with ethyl acetate (100 mL). The organic layer was washed with saturated sodium bicarbonate (3×) and dried over magnesium sulfate The solvent was evaporated to give 2-phenyl-5-ethyl-oxazole-4-carboxylic acid (4-piperidin-4-yl-phenyl)-amide (155 mg). LC-MS calcd for C23H25N3O2 (m/e) 375, obsd 376 (M+H).

Aufarbeitung

  1. customSolvents were evaporated
  2. additionthe residue was diluted with ethyl acetate (100 mL)
  3. washThe organic layer was washed with saturated sodium bicarbonate (3×)
  4. dry with materialdried over magnesium sulfate The solvent
  5. customwas evaporated

Quellen und Nachweise

ORD-Eintrag
ord-be893f4ee82d41728485a7b4366356dc
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08211914B2

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