3-Fluorobenzonitrile → 4-(3-Cyanophenyloxy)-6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridine

HRID 1511637

Reaktionsgleichung

Reaktionsgleichung von HRID 1511637
[CH3:1][N:2]1[CH2:7][CH:6]([OH:8])[C:5]2[CH:9]=[CH:10][O:11][C:4]=2[CH2:3]1.F[C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[C:16]#[N:17]>>[C:16]([C:15]1[CH:14]=[C:13]([O:8][CH:6]2[CH2:7][N:2]([CH3:1])[CH2:3][C:4]3[O:11][CH:10]=[CH:9][C:5]2=3)[CH:20]=[CH:19][CH:18]=1)#[N:17]

Komponenten

3

Edukt 2

HCID 678803-FluorobenzonitrileHCID 133651566-Methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol

Produkt 1

HCID 684121744-(3-Cyanophenyloxy)-6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridine

Versuchsvorschrift

The same method as in Example 1 was conducted using 6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol (Reference Example 1) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3-fluorobenzonitrile instead of 1-fluoronaphthalene to give the objective compound.

Aufarbeitung

  1. customto give the objective compound

Quellen und Nachweise

ORD-Eintrag
ord-4cf7fe18948b4cf89ad545f9986dfd97
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08217031B2

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