Benzene, 1-fluoro-4-(trifluoromethyl)- → 2,7-Dimethyl-4-[4-(trifluoromethyl)phenyloxy]-5,6,7,8-tetrahydro-4h-furo[2,3-c]azepine

HRID 1511670

Reaktionsgleichung

Reaktionsgleichung von HRID 1511670
[CH3:1][C:2]1[O:13][C:5]2[CH2:6][N:7]([CH3:12])[CH2:8][CH2:9][CH:10]([OH:11])[C:4]=2[CH:3]=1.F[C:15]1[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=1>>[CH3:1][C:2]1[O:13][C:5]2[CH2:6][N:7]([CH3:12])[CH2:8][CH2:9][CH:10]([O:11][C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=3)[C:4]=2[CH:3]=1

Komponenten

3

Edukt 2

HCID 67873Benzene, 1-fluoro-4-(trifluoromethyl)-HCID 684101192,7-dimethyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol

Produkt 1

HCID 684107442,7-Dimethyl-4-[4-(trifluoromethyl)phenyloxy]-5,6,7,8-tetrahydro-4h-furo[2,3-c]azepine

Versuchsvorschrift

The same method as in Example 1 was conducted using 2,7-dimethyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 20) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-fluoro benzotrifluoride instead of 1-fluoronaphthalene to give the objective compound.

Aufarbeitung

  1. customto give the objective compound

Quellen und Nachweise

ORD-Eintrag
ord-9ee0073831d14f288b64c92ad6c8119c
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08217031B2

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