1-Bromo 4-fluoronaphthalene → 8-(4-Bromonaphthalen-1-yloxy)-5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepine

HRID 1511685

Reaktionsgleichung

Reaktionsgleichung von HRID 1511685
[CH3:1][N:2]1[CH2:8][CH2:7][CH:6]([OH:9])[C:5]2[O:10][CH:11]=[CH:12][C:4]=2[CH2:3]1.[Br:13][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17](F)=[CH:16][CH:15]=1>>[Br:13][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17]([O:9][CH:6]2[CH2:7][CH2:8][N:2]([CH3:1])[CH2:3][C:4]3[CH:12]=[CH:11][O:10][C:5]2=3)=[CH:16][CH:15]=1

Komponenten

3

Edukt 2

HCID 676471-Bromo 4-fluoronaphthaleneHCID 684099105-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepin-8-ol

Produkt 1

HCID 684115548-(4-Bromonaphthalen-1-yloxy)-5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepine

Versuchsvorschrift

The same method as in Example 1 was conducted using 5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepin-8-ol (Reference Example 21) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 1-bromo-4-fluoronaphthalene instead of 1-fluoronaphthalene to give the objective compound.

Aufarbeitung

  1. customto give the objective compound

Quellen und Nachweise

ORD-Eintrag
ord-5dc442aa96c64b49974efe6cfeb198a5
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08217031B2

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