1-Chloro-4-fluoro-2-nitrobenzene → 4-(4-Chloro-3-nitrophenyloxy)-6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridine

HRID 1511694

Reaktionsgleichung

Reaktionsgleichung von HRID 1511694
[CH3:1][N:2]1[CH2:7][CH:6]([OH:8])[C:5]2[CH:9]=[CH:10][O:11][C:4]=2[CH2:3]1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16](F)=[CH:15][C:14]=1[N+:20]([O-:22])=[O:21]>>[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([O:8][CH:6]2[CH2:7][N:2]([CH3:1])[CH2:3][C:4]3[O:11][CH:10]=[CH:9][C:5]2=3)=[CH:15][C:14]=1[N+:20]([O-:22])=[O:21]

Komponenten

3

Edukt 2

HCID 676591-Chloro-4-fluoro-2-nitrobenzeneHCID 133651566-Methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol

Produkt 1

HCID 684115084-(4-Chloro-3-nitrophenyloxy)-6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridine

Versuchsvorschrift

The same method as in Example 1 was conducted using 6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol (Reference Example 1) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2-chloro-5-fluoronitrobenzene instead of 1-fluoronaphthalene to give the objective compound.

Aufarbeitung

  1. customto give the objective compound

Quellen und Nachweise

ORD-Eintrag
ord-c0c5354e1d524cdbb799dd0462bed2c6
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08217031B2

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