2-Fluoronaphthalene → 2,7-Dimethyl-4-(naphthalen-2-yloxy)-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine

HRID 1511701

Reaktionsgleichung

Reaktionsgleichung von HRID 1511701
[CH3:1][C:2]1[O:13][C:5]2[CH2:6][N:7]([CH3:12])[CH2:8][CH2:9][CH:10]([OH:11])[C:4]=2[CH:3]=1.F[C:15]1[CH:24]=[CH:23][C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=1>>[CH3:1][C:2]1[O:13][C:5]2[CH2:6][N:7]([CH3:12])[CH2:8][CH2:9][CH:10]([O:11][C:15]3[CH:24]=[CH:23][C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[CH:16]=3)[C:4]=2[CH:3]=1

Komponenten

3

Edukt 2

HCID 675832-FluoronaphthaleneHCID 684101192,7-dimethyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol

Produkt 1

HCID 684099272,7-Dimethyl-4-(naphthalen-2-yloxy)-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine

Versuchsvorschrift

The same method as in Example 1 was conducted using 2,7-dimethyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 20) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2-fluoronaphthalene instead of 1-fluoronaphthalene to give the objective compound.

Aufarbeitung

  1. customto give the objective compound

Quellen und Nachweise

ORD-Eintrag
ord-4350c3bd890348979aaae79f5c004fcc
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08217031B2

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