1-Cyano-4-fluoronaphthalene → 7-(4-Cyanonaphthalen-1-yloxy)-5-ethyl-2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

HRID 1511752

Reaktionsgleichung

Reaktionsgleichung von HRID 1511752
[CH2:1]([N:3]1[CH2:8][CH:7]([OH:9])[C:6]2[S:10][C:11]([CH3:13])=[CH:12][C:5]=2[CH2:4]1)[CH3:2].[C:14]([C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:19](F)=[CH:18][CH:17]=1)#[N:15]>>[C:14]([C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:19]([O:9][CH:7]2[CH2:8][N:3]([CH2:1][CH3:2])[CH2:4][C:5]3[CH:12]=[C:11]([CH3:13])[S:10][C:6]2=3)=[CH:18][CH:17]=1)#[N:15]

Komponenten

3

Edukt 2

HCID 27367341-Cyano-4-fluoronaphthaleneHCID 684124605-Ethyl-2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol

Produkt 1

HCID 684096627-(4-Cyanonaphthalen-1-yloxy)-5-ethyl-2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Versuchsvorschrift

The same method as in Example 1 was conducted using 5-ethyl-2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol (Reference Example 32) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-cyano-1-fluoronaphthalene instead of 1-fluoronaphthalene to give the objective compound.

Aufarbeitung

  1. customto give the objective compound

Quellen und Nachweise

ORD-Eintrag
ord-5d184210c8a54d2eb5d987d988b4a169
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08217031B2

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