2,3-Bis(trifluoromethyl)aniline → 1-(2,3-Bis(trifluoromethyl)phenyl)-3-(2-fluoropyridin-3-ylmethyl)thiourea

HRID 1512349Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1512349
[F:1][C:2]([F:15])([F:14])[C:3]1[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][CH:6]=[CH:5][C:4]=1[NH2:13].[F:16][C:17]1[C:22]([CH2:23][NH2:24])=[CH:21][CH:20]=[CH:19][N:18]=1.ClC1C(Cl)=CC=CC1(N=[C:35]=[S:36])F>>[F:1][C:2]([F:14])([F:15])[C:3]1[C:8]([C:9]([F:11])([F:12])[F:10])=[CH:7][CH:6]=[CH:5][C:4]=1[NH:13][C:35]([NH:24][CH2:23][C:22]1[C:17]([F:16])=[N:18][CH:19]=[CH:20][CH:21]=1)=[S:36]

Komponenten

4

Edukt 3

HCID 199806622,3-Bis(trifluoromethyl)anilineHCID 45079719(2-Fluoropyridin-3-yl)methanamineHCID 866035332,3-Dichloro-1-fluorophenylisothiocyanate

Produkt 1

HCID 866035321-(2,3-Bis(trifluoromethyl)phenyl)-3-(2-fluoropyridin-3-ylmethyl)thioureaAusbeute 90 %

Versuchsvorschrift

Prepared in 90% yield from the product of Example 197A and the product of Example 193C according to the procedure described for the product of Example 192D and Example 192G.

Quellen und Nachweise

ORD-Eintrag
ord-0050cafd984049f387cbcb8b50ca2de6
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08217067B2

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