Chlorosuccinimide → 2-Amino-5-chloro-3-nitrobenzamide

HRID 1512704Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1512704
[NH2:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[Cl:14]N1C(=O)CCC1=O>C(#N)C>[NH2:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:8]([Cl:14])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5]

Komponenten

4

Edukt 2

HCID 31398ChlorosuccinimideHCID 107974762-Amino-3-nitrobenzamide

Produkt 1

HCID 251933202-Amino-5-chloro-3-nitrobenzamideAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

2-Amino-3-nitrobenzamide (4.0 g) in warm anhydrous acetonitrile (1.25 L) was treated with N-chlorosuccinimide (3.1 g) at 60° C. under nitrogen for 20 hours. The mixture was allowed to cool to room temperature and filtered. The filter cake was washed with acetonitrile and dried to provide the title compound (3.98 g, 84%). MS (DCI/NH3) m/z 216 (M+H)+.

Aufarbeitung

  1. filtrationfiltered
  2. washThe filter cake was washed with acetonitrile
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9504092d5b6c4e348f26e01c38e22ef9
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08217070B2

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