Potassium Iodide → Ethyl 3-[4-(3-nitrophenyl)piperazino]propanoate

HRID 1514157

Reaktionsgleichung

Reaktionsgleichung von HRID 1514157
Cl.[N+:2]([C:5]1[CH:6]=[C:7]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH:8]=[CH:9][CH:10]=1)([O-:4])=[O:3].Br[CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(#N)C>[N+:2]([C:5]1[CH:6]=[C:7]([N:11]2[CH2:16][CH2:15][N:14]([CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:13][CH2:12]2)[CH:8]=[CH:9][CH:10]=1)([O-:4])=[O:3]

Komponenten

6

Edukt 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 68320Ethyl 3-bromopropionateHCID 27602151-(3-nitrophenyl)piperazine Hydrochloride

Produkt 1

HCID 59536469Ethyl 3-[4-(3-nitrophenyl)piperazino]propanoateAusbeute 91,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A mixture of 1-(3-nitrophenyl)piperazine hydrochloride (2.6 g, 10.66 mmol), ethyl 3-bromopropionate (2.41 g, 1.7 mL, 13.32 mmol), potassium carbonate (6.1 g, 44.13 mmol) and a catalytic amount of potassium iodide in acetonitrile (30 mL) was heated at reflux for 18 hrs. After cooling to room temperature the solvent was evaporated under reduced pressure and the residue was taken up in dichloromethane. The organic phase was washed with water, dried over MgSO4 and evaporated to dryness to afford 3.00 g (91.5%) ethyl 3-[4-(3-nitrophenyl)piperazino]propanoate D6 as an orange oil which crystallised on standing.

Aufarbeitung

  1. temperatureat reflux for 18 hrs
  2. customwas evaporated under reduced pressure
  3. washThe organic phase was washed with water
  4. dry with materialdried over MgSO4
  5. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-d881c4344a1544e2addc24a5c274a5da
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08222254B2

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