Hydrogen Bromide → HCID 59403478, Verbindung
Reaktionsgleichung
C[O:2][C:3]1[CH:14]=[CH:13][C:6]2[C:7](=[O:12])[NH:8][CH2:9][CH2:10][O:11][C:5]=2[CH:4]=1.Br>>[OH:2][C:3]1[CH:14]=[CH:13][C:6]2[C:7](=[O:12])[NH:8][CH2:9][CH2:10][O:11][C:5]=2[CH:4]=1Komponenten
3
Reaktionsbedingungen
- Temperatur
- 110 °C
Versuchsvorschrift
A mixture of 8-(methyloxy)-3,4-dihydro-1,4-benzoxazepin-5(2H)-one (Preparation 25) (7.98 g, 41.3 mmol) and hydrobromic acid (100 ml, 1842 mmol) was stirred and heated at 110° C. for 7 hours. Then the reaction mixture was evaporated and azeotroped twice with 150 ml of ethanol to give the title compound (8.66 g) light brown solid which was used without purification. MS (ES) C9H9NO3 requires 179; found 180 [M+H]+.
Aufarbeitung
- customThen the reaction mixture was evaporated
- customazeotroped twice with 150 ml of ethanol
Quellen und Nachweise
- ORD-Eintrag
- ord-8e86bd5396de46cf86608ab125613222
- Quelldatensatz
- uspto-grants-2012_07
- Patentnummer
- US08222245B2
Notizen zur Reaktion
Wird geladen…