Methanol → 2-Methanesulfonyl-5-methyl-4-pyridin-3-yl-pyrimidine

Reaktionsgleichung

[CH3:1][C:2]1[C:3]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[N:4][C:5](SC)=[N:6][CH:7]=1.O[O:17][S:18]([O-:20])=O.[K+].[CH3:22]O>>[CH3:22][S:18]([C:5]1[N:4]=[C:3]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[C:2]([CH3:1])=[CH:7][N:6]=1)(=[O:20])=[O:17]

Komponenten

Edukt 3

HCID 887Methanol

HCID 23707502Potassium hydroxy sulfite

HCID 59242786HCID 59242786, Verbindung

Produkt 1

HCID 686973182-Methanesulfonyl-5-methyl-4-pyridin-3-yl-pyrimidineAusbeute 88 %

Versuchsvorschrift

A solution of 5-methyl-2-methylsulfanyl-4-pyridin-3-yl-pyrimidine (1.28 g, 5.90 mmol) in MeOH (45 ml) was cooled at 0° C. and then an aqueous solution of oxone (11 g, 17.95 mmol in 45 ml of water) was added dropwise. After 15 minutes, ice bath was removed and the stirring continue for 3 hours. The mixture was neutralized with solid NaHCO3 and the product was extracted with ethyl acetate. The organic phase was dried (Na2SO4) and evaporated to give 1.3 g of the title compound as a white powder (88% yield).