(5-[(1,1-Dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate → {5-[(1,1-Dimethylethyl)thio]-4-oxo-1,4-dihydro-2-pyridinyl}methyl acetate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	(5-[(1,1-Dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate	HCID 68598711	—
Katalysator	Palladium	HCID 23938	—
Lösungsmittel	1,4-Dioxane--water (1/1)	HCID 21886435	—
Produkt	{5-[(1,1-Dimethylethyl)thio]-4-oxo-1,4-dihydro-2-pyridinyl}methyl acetate	HCID 67526579	100,6%

Reaktionsschritte

A solution of (5-[(1,1-dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate (6 g) in 1,4-dioxane/water (100 ml/50 ml) was hydrogenated at atmospheric pressure with 10% palladium on charcol (7 g) overnight. Filtration and evaporation afforded a white solid (4.46 g, 95%).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07732460B2
Quelldatensatz	uspto-grants-2010_06
ORD ID	ord-50588ac79e3c4fe893f88290c98fec15
Quellennotiz	uspto-grants-2010_06