Ethyl Acetate → 4-[3-Cyano-4-(2-hydroxyphenyl)pyrrole-1-yl]-2-methoxymethoxy benzoic acid ethyl ester

HRID 1516587Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1516587
[CH2:1]([O:3][C:4](=[O:36])[C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH:15]=[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[O:22]CC3C=CC=CC=3)[C:13]([C:30]#[N:31])=[CH:12]2)=[C:7](OC)[C:6]=1[O:34][CH3:35])[CH3:2].[C:37](OCC)(=[O:39])C>[C].[Pd].CO>[CH2:1]([O:3][C:4](=[O:36])[C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH:15]=[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[OH:22])[C:13]([C:30]#[N:31])=[CH:12]2)=[CH:7][C:6]=1[O:34][CH2:35][O:39][CH3:37])[CH3:2]

Komponenten

5

Edukt 2

HCID 8857Ethyl AcetateHCID 685077024-[4-(2-Benzyloxyphenyl)-3-cyanopyrrole-1-yl]-2-methoxy-methoxy-benzoic acid ethyl ester

Produkt 1

HCID 594776664-[3-Cyano-4-(2-hydroxyphenyl)pyrrole-1-yl]-2-methoxymethoxy benzoic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 4-[4-(2-benzyloxyphenyl)-3-cyanopyrrole-1-yl]-2-methoxy-methoxy-benzoic acid ethyl ester (2.3 g) in a mixed solvent of ethyl acetate (20 mL) and methanol (20 mL) was added palladium-carbon powder under an argon atmosphere, and this mixture was stirred at room temperature under a hydrogen atmosphere for 5 hours. The insoluble material was removed by filtration, and this filtrate was concentrated under reduced pressure to give the title compound (1.4 g)

Aufarbeitung

  1. customThe insoluble material was removed by filtration
  2. concentrationthis filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5ad66f57b43b458b9d8ecc01a3c47880
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08227500B2

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