Methanol → 2-(3-Cyano-4-phenylpyrrole-1-yl)-5-hydroxyisonicotinic acid ethyl ester

HRID 1516603Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1516603
[CH2:1]([O:3][C:4](=[O:32])[C:5]1[C:10]([O:11]CC2C=CC=CC=2)=[CH:9][N:8]=[C:7]([N:19]2[CH:23]=[C:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:21]([C:30]#[N:31])=[CH:20]2)[CH:6]=1)[CH3:2].CO>[C].[Pd].C(OCC)(=O)C>[CH2:1]([O:3][C:4](=[O:32])[C:5]1[C:10]([OH:11])=[CH:9][N:8]=[C:7]([N:19]2[CH:23]=[C:22]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[C:21]([C:30]#[N:31])=[CH:20]2)[CH:6]=1)[CH3:2]

Komponenten

5

Edukt 2

HCID 887MethanolHCID 594778055-Benzyloxy-2-(3-cyano-4-phenylpyrrole-1-yl)isonicotinic acid ethyl ester

Produkt 1

HCID 594778862-(3-Cyano-4-phenylpyrrole-1-yl)-5-hydroxyisonicotinic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 5-benzyloxy-2-(3-cyano-4-phenylpyrrole-1-yl)isonicotinic acid ethyl ester in a mixed solvent of methanol (2 mL) and ethyl acetate (2 mL) was added palladium-carbon powder (0.020 g), and this mixture was stirred at room temperature under a hydrogen atmosphere for 30 minutes. The insoluble material was removed by suction through a Celite pad. This filtrate was concentrated under reduced pressure. This obtained solid was washed with diethyl ether, dried to give the title compound (0.040 g).

Aufarbeitung

  1. customThe insoluble material was removed by suction through a Celite pad
  2. concentrationThis filtrate was concentrated under reduced pressure
  3. washThis obtained solid was washed with diethyl ether
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-aaab336be6614b728a40df4471a6e34f
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08227500B2

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