Sodium Chloride → 1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonic acid;2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide

HRID 1517223

Reaktionsgleichung

Reaktionsgleichung von HRID 1517223
[CH3:1][CH2:2][N:3]([CH2:6][C:7]([NH:9][C:10]1[C:11]([CH3:17])=[CH:12][CH:13]=[CH:14][C:15]=1[CH3:16])=[O:8])[CH2:4][CH3:5].Cl.[Na].[CH3:20][CH2:21][CH2:22][CH2:23][CH:24]([CH2:27][O:28][C:29]([CH2:31][CH:32]([S:44]([OH:47])(=[O:46])=[O:45])[C:33]([O:35][CH2:36][CH:37]([CH2:40][CH2:41][CH2:42][CH3:43])[CH2:38][CH3:39])=[O:34])=[O:30])[CH2:25][CH3:26].[Na+].[Cl-].C(Cl)(Cl)Cl>CO>[CH3:5][CH2:4][N:3]([CH2:6][C:7]([NH:9][C:10]1[C:15]([CH3:16])=[CH:14][CH:13]=[CH:12][C:11]=1[CH3:17])=[O:8])[CH2:2][CH3:1].[CH3:20][CH2:21][CH2:22][CH2:23][CH:24]([CH2:27][O:28][C:29]([CH2:31][CH:32]([S:44]([OH:47])(=[O:46])=[O:45])[C:33]([O:35][CH2:36][CH:37]([CH2:40][CH2:41][CH2:42][CH3:43])[CH2:38][CH3:39])=[O:34])=[O:30])[CH2:25][CH3:26]

Komponenten

6

Edukt 4

HCID 5234Sodium Chloride2×HCID 6212Chloroform2×HCID 6314Lidocaine HydrochlorideHCID 9955175Sodium docusate

Produkt 1

HCID 177558781,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonic acid;2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Lidocaine hydrochloride (0.0188 mol) was dissolved in 50 mL methanol and sodium docusate [bis(2-ethylhexyl)sulfosuccinate sodium salt] (0.0188 mol) was dissolved in 50 mL. The two solutions were combined and stirred for two hours, during this time a white precipitate (NaCl) formed. The methanol was removed by rotary evaporation which leaves a white sticky solid. To this solid, 150 mL of chloroform was added. A portion of the product dissolved the chloroform while the byproduct (NaCl) remained as a suspended solid. The NaCl was removed by filitration, and the solvent was removed by rotary evaporation. The product, lidocaine docusate, is a colorless syrup and is dried under high vacuum. 1H and 13C NMR (CDCl3) were obtained.

Aufarbeitung

  1. customformed
  2. customThe methanol was removed by rotary evaporation which
  3. customleaves a white sticky solid
  4. customThe NaCl was removed by filitration
  5. customthe solvent was removed by rotary evaporation
  6. customis dried under high vacuum
  7. custom1H and 13C NMR (CDCl3) were obtained

Quellen und Nachweise

ORD-Eintrag
ord-78cd1f5ba64544ea9ff536906c2385a6
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08232265B2

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