Phosphorus sulfide (P2S5) → HCID 178508162, Verbindung

HRID 1517436Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1517436
[NH2:1][C:2]1[NH:3][C:4](=O)[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:21]>N1C=CC=CC=1>[NH2:1][C:2]1[NH:3][C:4](=[S:21])[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1

Komponenten

4

Edukt 2

HCID 14817Phosphorus sulfide (P2S5)HCID 1361375922-Amino-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidin-4(1H)-one

Produkt 1

HCID 178508162HCID 178508162, VerbindungAusbeute 73 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

A suspension of 2-amino-6-(4-fluorophenyl)-pyrido(3,2-d)pyrimidin-4(3H)one (2.56 g, 10 mmol) and phosphorus pentasulfide (2.5 g, 11 mmol) in pyridine (200 ml) was refluxed for 4 hours. The reaction mixture was cooled down and the precipitate was filtered off, yielding the pure title compound, which was used without any further purification (2 g, yield: 73%) and was characterised by its mass spectrum as follows: MS (m/z): 273 ([M+H]+, 100)

Aufarbeitung

  1. temperaturewas refluxed for 4 hours
  2. temperatureThe reaction mixture was cooled down
  3. filtrationthe precipitate was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-3be6260680fb44ed9031d67400c11124
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08232278B2

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