Triethylamine → HCID 69453076, Verbindung

HRID 1517633Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1517633
[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C@H:10]([NH:14][C:15]([NH:17][C:18]1[CH:26]=[CH:25][CH:24]=[C:23]3[C:19]=1[CH:20]=[N:21][N:22]3[C:27]([O:29][CH2:30][P:31](=[O:34])([OH:33])[OH:32])=[O:28])=[O:16])[CH2:9][CH2:8]2)([CH3:4])([CH3:3])[CH3:2].[CH2:35]([N:37]([CH2:40][CH3:41])[CH2:38][CH3:39])[CH3:36]>CO>[CH2:35]([N:37]([CH2:40][CH3:41])[CH2:38][CH3:39])[CH3:36].[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C@H:10]([NH:14][C:15]([NH:17][C:18]1[CH:26]=[CH:25][CH:24]=[C:23]3[C:19]=1[CH:20]=[N:21][N:22]3[C:27]([O:29][CH2:30][P:31](=[O:32])([OH:34])[OH:33])=[O:28])=[O:16])[CH2:9][CH2:8]2)([CH3:4])([CH3:2])[CH3:3]

Komponenten

4

Edukt 2

HCID 8471TriethylamineHCID 16226508HCID 16226508, Verbindung

Produkt 1

HCID 69453076HCID 69453076, VerbindungAusbeute 100,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Suspended 50.2 mg (103 μmol) of compound from Example 21D in 10 mL methanol, added 10.4 mg (103 μmol) triethylamine, stirred the colorless solution for 10 minutes at ambient temperature, concentrated and vacuum dried. Obtained 61 mg (100% yield) of the title compound as an off-white powder. 1H NMR (methanol-d4) δ: 1.29 (t, 9H), 1.32 (s, 9H), 1.90 (m, 1H), 2.59 (m, 1H), 2.89 (m, 1H), 3.00 (m, 1H), 3.16 (q, 6H), 4.54 (d, 2H), 5.29 (t, 1H), 7.28 (s, 2H), 7.31 (s, 1H), 7.52 (t, 1H), 7.74 (d, 1H), 7.97 (d, 1H), 8.36 (s, 1H). Anal Calcd for C23H27N4O6P.1.0 triethylamine.0.7 methanol: C, 58.47; H, 7.40; N, 11.48. Found: C, 58.46; H, 7.38; N, 11.44.

Aufarbeitung

  1. concentrationconcentrated
  2. customvacuum dried

Quellen und Nachweise

ORD-Eintrag
ord-97fafbc949604f82bbb64d782a995058
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08232309B2

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