Potassium Hydroxide → N-(3-fluoro-4-(7-((1-hydroxycyclopropyl)methoxy)quinolin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

HRID 1517876Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1517876
C([O:4][C:5]1([CH2:8][O:9][C:10]2[CH:19]=[C:18]3[C:13]([C:14]([O:20][C:21]4[CH:26]=[CH:25][C:24]([NH:27][C:28]([C:30]5[C:31](=[O:43])[N:32]([C:37]6[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=6)[N:33]([CH3:36])[C:34]=5[CH3:35])=[O:29])=[CH:23][C:22]=4[F:44])=[CH:15][CH:16]=[N:17]3)=[CH:12][CH:11]=2)[CH2:7][CH2:6]1)(=O)C.[OH-].[K+]>CO>[F:44][C:22]1[CH:23]=[C:24]([NH:27][C:28]([C:30]2[C:31](=[O:43])[N:32]([C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=3)[N:33]([CH3:36])[C:34]=2[CH3:35])=[O:29])[CH:25]=[CH:26][C:21]=1[O:20][C:14]1[C:13]2[C:18](=[CH:19][C:10]([O:9][CH2:8][C:5]3([OH:4])[CH2:6][CH2:7]3)=[CH:11][CH:12]=2)[N:17]=[CH:16][CH:15]=1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 66684940HCID 66684940, Verbindung

Produkt 1

HCID 66670625N-(3-fluoro-4-(7-((1-hydroxycyclopropyl)methoxy)quinolin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamideAusbeute 100,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of compounds 1-((4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)quinolin-7-yloxy)methyl)cyclopropyl acetate (110 mg, 0.18 mmol) in 8 mL of methanol was added KOH (100 mg, 1.78 mmol) slowly. After stirring at rt for 0.5 hr, the reaction mixture was filtered and the solid was washed with ethyl acetate (10 mL×2) to give the title compound as a white solid (100 mg, 29%).

Aufarbeitung

  1. filtrationthe reaction mixture was filtered
  2. washthe solid was washed with ethyl acetate (10 mL×2)

Quellen und Nachweise

ORD-Eintrag
ord-00fd4e165355417eae1104d3a58a8bba
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08232294B2

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