Benzyl Bromide → Propanoic acid, 3-hydroxy-, phenylmethyl ester

Temperatur

80 °C

3-Hydroxypropanoic acid solution (12 g, 40 mmol, 30% in H2O solution, TCI, TOKYOKASEI) and KOH (2.24 g, 40 mmol, Shantou Xilong chemical factory) was stirred at rt for 30 min, the mixture was concentrated in vacuo to give a white solid. The solid was suspended in 50 mL of DMF was added BnBr (4.75 mL, 40 mmol, Aldrich) via a syringe at rt. After stirring at 80° C. for 5 h, the reaction mixture concentrated in vacuo. The residue was purified by a silica gel column chromatography (10:1 (v/v) petroleum ether/EtOAc) to give the title compound as colorless oil (3.35 g, 46%).

1. concentrationthe mixture was concentrated in vacuo
2. customto give a white solid
3. concentrationthe reaction mixture concentrated in vacuo
4. customThe residue was purified by a silica gel column chromatography (10:1 (v/v) petroleum ether/EtOAc)

ORD-Eintrag

ord-2a9ad32a592d4858a483b721b6d082b9

Quelldatensatz

uspto-grants-2012_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08232294B2