1-Bromo-2,6-difluorobenzene → 2',6'-Difluoro-5-methyl-biphenyl-3,4-diamine
Reaktionsgleichung
[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5](B2OC(C)(C)C(C)(C)O2)=[CH:4][C:3]=1[N+:18]([O-])=O.Br[C:22]1[C:27]([F:28])=[CH:26][CH:25]=[CH:24][C:23]=1[F:29]>>[F:28][C:27]1[CH:26]=[CH:25][CH:24]=[C:23]([F:29])[C:22]=1[C:5]1[CH:6]=[C:7]([CH3:8])[C:2]([NH2:1])=[C:3]([NH2:18])[CH:4]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared from 2-methyl-6-nitro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine (as prepared in Example 8, step A) and 2-bromo-1,3-difluoro-benzene according to the procedures described in Example 4, step A and Example 1, step E. 1H-NMR (400 MHz, CDCl3) δ: 7.17 (tt, J=8.3, 6.3 Hz, 1H), 6.87-6.97 (m, 2H), 6.76 (s, 1H), 6.72 (s, 1H), 3.44 (br. s., 4H), 2.21 (s, 3H).
Quellen und Nachweise
- ORD-Eintrag
- ord-408a4cada5574982b55c40b9c8755511
- Quelldatensatz
- uspto-grants-2012_07