HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Phenylpiperazine → 4-(4-Methyl-1-piperazinyl)phenol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Phenylpiperazine | HCID 7096 | — |
| Edukt | p-(1-Piperazinyl)phenol | HCID 92467 | — |
| Edukt | ethyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-iodobutyl)thiazole-4-carboxylate | HCID 59447633 | — |
| Edukt | methyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-((4-phenylpiperazin-1-yl)methyl)thiazole-4-carboxylate | HCID 59447670 | — |
| Produkt | 4-(4-Methyl-1-piperazinyl)phenol | HCID 11622486 | — |
Reaktionsschritte
Compound 82A was prepared in a similar manner to the synthesis of compound 62A by substituting compound 42C and phenylpiperazine with paraformahyde and 4-(piperazin-1-yl)phenol, respectively: 1H NMR (DMSO-d6): δ 6.74-6.78 (m, 2H), 6.61-6.65 (m, 2H), 2.93-2.95 (m, 4H), 2.41-2.44 (m, 4H), 2.22 (s, 3H). ESI (+)/MS: 193 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08232273B2 |
| Quelldatensatz | uspto-grants-2012_07 |
| ORD ID | ord-c44754f63d45453c8eabc1be3f99d5d3 |
| Quellennotiz | uspto-grants-2012_07 |